If your speaker set uses just one soundcard speaker out port, you should not have problems. If it requires 2 seperate speaker ports, you will need to get a sound card that supports 4 or more speakers. Sound blaster offers the pci 128 and the sound blaster live card. You could look at a diamond mx200 or mx300 monster sound cards. All of these cards support 4 speakers. The mx300 or the sb live are the best of those, but any of them would be good sound cards. Stick to the live or mx series if good 3d positional audio is really important to you. Good luck.