There is an advantage to having a smaller boot partition (2-4Gig) when you have two drives. You can ghost the boot partition to your second drive and have a fast and reliable way to get things working well if the computer gets glitchy. You are also up and running fast with a drive failure on your boot drive. Even with all of your programs installed on the boot partition the ghost is usually smaller than a Gig due to compression.
Otherwise I donít see where partitions are any better for organizing your stuff than just using folders. You can squeeze more stuff on the drives by keeping the cluster size down to 4k by restricting your partitions to 8Gigs, but the FAT gets too large with as much space as you have. Large files like MP3s and graphics work better with larger clusters anyway.
If you can keep your head while others around you are losing theirs, then there is something you don't know