I was asked to create this sticky, but it's something I'd also been thinking about doing for a while, being the open-source advocate I am. The ones I'll initially list are ones I've personally tested against other software and continue to use.
SourceForge - Comprehensive directory of open-source projects.
WEBI.ORG - Free and Open Source Software Directory.
Open Source Alternatives - Find open source software alternatives to well-known commercial software.
AlternativeTo - Provides a large list of open-source and other alternatives to popular commercial software.
StarDict - Cross-Platform and international dictionary Software. It has powerful features such as "Glob-style pattern matching", "Scan selection word," "Fuzzy query," etc.
Internet Browsers / Email Clients
Mozilla Firefox - Extremely popular web browser, made very personalised and modular by the availability of extensions.
Mozilla Thunderbird - Email client, made very personalised and modular by the availability of extensions.
OpenWengo - VoIP software that lets you enjoy free calls, video conferencing, SMS and chat over many existing protocols (MSN, AIM/ICQ, Yahoo!, Jabber).
SIP Communicator - Audio/video Internet phone and instant messenger that supports popular instant messaging and telephony protocols such as SIP, Jabber, AIM/ICQ, MSN, etc.
Open Kiosk - Kiosk management system suited for use in controlled computing environments such as public access systems, libraries, school computer laboratories and internet cafes.
Clonezilla - Drive cloning (like Ghost) and system deployment.
Partition Logic - Hard disk partitioning and data management.
Rufus - A small utility that helps format and create bootable USB flash drives, such as USB keys/pendrives, memory sticks, etc.
Synergy - Share a single mouse and keyboard between multiple computers with different operating systems, each with its own display, without special hardware. Imagine the functionality of dual monitors (expanded desktop) except each monitor is connected to a different computer.
Bookmarks